Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Geranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production
Qinghao Jin, Chul Lee, Jin Woo Lee, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Jin Sook Kim, Joo-Hwan Kim, Mi Kyeong Lee, Bang Yeon Hwang
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Keywords: Paulownia coreana, Paulowniaceae, geranylated flavanone, nitric oxide inhibitor
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2015 Volume 63 Issue 5 Pages 384-387

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Abstract
The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3′-O-methyl-5′-hydroxydiplacol (1), along with 10 known compounds (2–11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1–6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 µM.
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© 2015 The Pharmaceutical Society of Japan
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